Hoff G, Moen I E, Trygg K, Frølich W, Sauar J, Vatn M, Gjone E, Larsen S
Scand J Gastroenterol. 1986 Mar;21(2):199-204. doi: 10.3109/00365528609034647.
Epidemiological studies have suggested an association between diet and colorectal cancer. Case/control studies, however, have been scarce, and studies based on interview with cancer patients who have symptoms from their cancer are inevitably prone to bias. An endoscopic population screening study for detection of colorectal adenomas enabled a double-blind registration of diet during 5 consecutive weekdays. Neither the participant nor the dietitian was informed of the findings at endoscopy. The estimation of 23 nutritional components was based on analysis of local commercial food and on the composition of foods in Norway. Results showed increasing consumption of fat and decreasing consumption of fiber and cruciferous vegetables in the presence of increasing neoplastic changes. The present material will form the basis for dietary-related follow-up studies.
流行病学研究表明饮食与结直肠癌之间存在关联。然而，病例对照研究却很匮乏，而且基于对有癌症症状的癌症患者进行访谈的研究不可避免地容易产生偏差。一项用于检测结直肠腺瘤的内镜人群筛查研究实现了连续五个工作日饮食的双盲记录。参与者和营养师均未被告知内镜检查结果。对23种营养成分的评估基于当地商业食品分析以及挪威食物的成分。结果显示，随着肿瘤性病变增加，脂肪摄入量增加，而纤维和十字花科蔬菜的摄入量减少。本研究资料将为与饮食相关的随访研究奠定基础。
