Hoff G, Foerster A, Vatn M H, Sauar J, Larsen S
Scand J Gastroenterol. 1986 Sep;21(7):853-62. doi: 10.3109/00365528609011130.
In an endoscopic population screening study for colorectal polyps among 200 men and 200 women, 50-59 years of age, 215 polyps less than 5 mm in diameter were left in situ for the present 2-year follow-up examination. The attendance rate was 102 of 106 (96%) for polyp patients and 77 of 90 (86%) in the control group. Of 194 polyps, 143 (74%) in the 102 polyp-bearing individuals were recovered for histological evaluation and 57 polyps were registered as new. Ninety-nine (50%) of the polyps were hyperplastic, 45 (23%) were adenomas, and 45 (23%) were mucosal tags. Both growth and regression of polyps were registered. Regression was commoner in the distal part of the rectum than in the proximal part or distal sigmoid colon. Growth was similar for recovered adenomas and hyperplastic polyps, whereas mucosal tags more often showed diminution in size. No polyp had reached a size of more than 5 mm in 2 years, and no case of severe dysplasia or carcinoma was registered. The estimated total polyp mass more than doubled both for adenomas and hyperplastic polyps. It is concluded that the time interval between initial examination with removal of polyps 5 mm or larger in diameter and the first follow-up examination may safely be set at 2 years.
在一项针对200名年龄在50 - 59岁的男性和200名女性进行的结直肠息肉内镜人群筛查研究中，215枚直径小于5毫米的息肉被留作原位观察，进行本次为期2年的随访检查。息肉患者的随访率为106人中的102人（96%），对照组为90人中的77人（86%）。在194枚息肉中，102名有息肉的个体中的143枚（74%）被回收用于组织学评估，57枚息肉被登记为新增息肉。99枚（50%）息肉为增生性息肉，45枚（23%）为腺瘤，45枚（23%）为黏膜赘生物。息肉的生长和消退情况均有记录。息肉消退在直肠远端比在近端或乙状结肠远端更常见。回收的腺瘤和增生性息肉的生长情况相似，而黏膜赘生物的大小更常减小。2年内没有息肉直径超过5毫米，也没有严重发育异常或癌变的病例记录。腺瘤和增生性息肉的估计息肉总量均增加了一倍多。结论是，首次检查时切除直径5毫米或更大的息肉与首次随访检查之间的时间间隔可以安全地设定为2年。
