Domenici L, Parisi V, Maffei L
Istituto di Neurofisiologia del CNR, Pisa, Italy.
Neuroscience. 1992 Nov;51(1):19-24. doi: 10.1016/0306-4522(92)90466-f.
It has recently been reported that exogenous supply of nerve growth factor prevents the effects of monocular deprivation both in rats and in cats. Here we have extended these experiments to the case of strabismus. Repeated intraventricular injections of nerve growth factor were performed in rats made surgically strabismic early in the critical period. At the end of the critical period the ocular dominance distribution of visual cortical neurons was assessed in strabismic untreated, strabismic nerve growth factor-treated and strabismic Cytochrome C-treated (control) rats by means of extracellular recordings. We found that in rats surgical strabismus causes a consistent loss of binocular neurons. By contrast the treatment with nerve growth factor maintains the normal ocular dominance distribution of neurons in the primary visual cortex. We conclude that nerve growth factor exogenously supplied prevents the effects induced by surgical strabismus in rats and suggest that nerve growth factor has a role in visual cortical plasticity.
最近有报道称，外源性供应神经生长因子可防止大鼠和猫出现单眼剥夺的影响。在此，我们将这些实验扩展到斜视的情况。在关键期早期通过手术造成斜视的大鼠中，反复进行脑室内注射神经生长因子。在关键期末，通过细胞外记录评估未治疗的斜视大鼠、接受神经生长因子治疗的斜视大鼠和接受细胞色素C治疗的斜视大鼠（对照）的视皮层神经元的眼优势分布。我们发现，手术性斜视会导致大鼠双眼神经元持续丧失。相比之下，神经生长因子治疗可维持初级视皮层神经元正常的眼优势分布。我们得出结论，外源性供应的神经生长因子可防止手术性斜视在大鼠中诱导产生的影响，并表明神经生长因子在视皮层可塑性中发挥作用。
