Yee Ada X, Hsu Yu-Tien, Chen Lu
Departments of Neurosurgery, Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305-5453, USA.
Departments of Neurosurgery, Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305-5453, USA
Philos Trans R Soc Lond B Biol Sci. 2017 Mar 5;372(1715). doi: 10.1098/rstb.2016.0155.
Hebbian and homeostatic plasticity are two major forms of plasticity in the nervous system: Hebbian plasticity provides a synaptic basis for associative learning, whereas homeostatic plasticity serves to stabilize network activity. While achieving seemingly very different goals, these two types of plasticity interact functionally through overlapping elements in their respective mechanisms. Here, we review studies conducted in the mammalian central nervous system, summarize known circuit and molecular mechanisms of homeostatic plasticity, and compare these mechanisms with those that mediate Hebbian plasticity. We end with a discussion of 'local' homeostatic plasticity and the potential role of local homeostatic plasticity as a form of metaplasticity that modulates a neuron's future capacity for Hebbian plasticity.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.
赫布可塑性为联想学习提供突触基础，而稳态可塑性则用于稳定网络活动。虽然实现的目标看似截然不同，但这两种可塑性类型在功能上通过各自机制中的重叠元素相互作用。在这里，我们回顾在哺乳动物中枢神经系统中进行的研究，总结稳态可塑性已知的回路和分子机制，并将这些机制与介导赫布可塑性的机制进行比较。我们最后讨论“局部”稳态可塑性以及局部稳态可塑性作为一种调节神经元未来赫布可塑性能力的元可塑性形式的潜在作用。本文是主题为“整合赫布可塑性和稳态可塑性”的特刊的一部分。
