Roach P D, Dowling K, Balasubramaniam S, Illman R J, Kambouris A M, Nestel P J, Topping D L
CSIRO, Division of Human Nutrition, Adelaide, NSW, Australia.
Atherosclerosis. 1992 Oct;96(2-3):219-26. doi: 10.1016/0021-9150(92)90068-r.
Male rats were fed a semi-purified diet containing oat bran or wheat bran with or without a marine fish oil to investigate the effects of such combinations on lipid metabolism. Oat bran alone and wheat bran plus fish oil gave lower plasma cholesterol concentrations than wheat bran alone while oat bran plus fish oil gave the lowest. Oat bran increased plasma triacylglycerols compared with wheat bran but oat bran plus fish oil gave concentrations similar to those seen with wheat bran plus fish oil. Oat bran gave higher hepatic cholesterol synthesis rates and a higher activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase compared to wheat bran. The addition of fish oil to either bran diet decreased cholesterol synthesis but HMG CoA reductase activity was not reduced. Oat bran increased hepatic acyl coenzyme A:cholesterol acyl transferase (ACAT) activity and increased the ratio of esterified to unesterified cholesterol in hepatic microsomal membranes compared with wheat bran. Fish oil decreased hepatic LDL receptor activity and increased HDL binding activity when added to the wheat bran diet but these effects were not seen with oat bran. Oat bran also had no effect on hepatic lipoprotein receptor activity compared with wheat bran. These results show that fish oil and oat bran have complementary cholesterol lowering effects in the rat.
给雄性大鼠喂食含有燕麦麸或麦麸的半纯化日粮，添加或不添加海鱼油，以研究这些组合对脂质代谢的影响。单独的燕麦麸和麦麸加鱼油组的血浆胆固醇浓度低于单独的麦麸组，而燕麦麸加鱼油组的血浆胆固醇浓度最低。与麦麸相比，燕麦麸会增加血浆甘油三酯，但燕麦麸加鱼油组的血浆甘油三酯浓度与麦麸加鱼油组相似。与麦麸相比，燕麦麸的肝脏胆固醇合成率更高，3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶的活性也更高。在两种麸皮日粮中添加鱼油均可降低胆固醇合成，但HMG CoA还原酶活性并未降低。与麦麸相比，燕麦麸会增加肝脏酰基辅酶A：胆固醇酰基转移酶（ACAT）的活性，并增加肝微粒体膜中酯化胆固醇与未酯化胆固醇的比例。添加到麦麸日粮中的鱼油会降低肝脏低密度脂蛋白受体活性并增加高密度脂蛋白结合活性，但燕麦麸日粮未出现这些效果。与麦麸相比，燕麦麸对肝脏脂蛋白受体活性也没有影响。这些结果表明，鱼油和燕麦麸在大鼠体内具有互补的降胆固醇作用。
