Nagasue N, Kohno H
Second Department of Surgery, Shimane Medical University, Izumo, Japan.
HPB Surg. 1992;6(1):1-6. doi: 10.1155/1992/72761.
The liver is morphologically and functionally modulated by sex hormones. Long-term use of oral contraceptives and androgenic steroids can induce benign and malignant hepatocellular tumors. Hepatocellular carcinoma (HCC) is more prevalent in men than in women. The role of sex hormones and their receptors in the development of HCC was reviewed. Some HCCs may be androgen dependent but others may be estrogen or even both dependent. Further studies are mandatory in order to utilize such characteristics of HCC for an effective prophylaxis and therapy of this tumor.
肝脏在形态和功能上受到性激素的调节。长期使用口服避孕药和雄激素类固醇可诱发良性和恶性肝细胞肿瘤。肝细胞癌（HCC）在男性中比在女性中更为普遍。本文综述了性激素及其受体在HCC发生发展中的作用。一些HCC可能依赖雄激素，但其他的可能依赖雌激素，甚至两者都依赖。为了利用HCC的这些特征对该肿瘤进行有效的预防和治疗，必须进行进一步的研究。
