De Maria Nicola, Manno Mauro, Villa Erica
Department of Medicine, Division of Gastroenterology, School of Medicine, University of Modena, Modena, Italy.
Mol Cell Endocrinol. 2002 Jul 31;193(1-2):59-63. doi: 10.1016/s0303-7207(02)00096-5.
Hepatocellular carcinoma (HCC) is one of the most common malignancy in the world and it usually occurs in individuals with chronic liver disease. The neoplasm is predominant in the male gender, where it is characterized also by a worst prognosis than in females. The pathogenesis of HCC is obscure. Because of its striking male predominance, androgens have been investigated as potential factors able to induce or at least promote hepatic carcinogenesis; this hypothesis has been also supported by the ability of androgens of inducing liver neoplasms in experimental models. On the other hand, due to the fact that HCC occurs predominantly in male cirrhotics who present a characteristic hormone imbalance with a relative hyperestrogenic state, the potential role of estrogen in liver cancer has been studied as well. In this paper, the potential role of sex hormones in liver carcinogenesis has been reviewed.
肝细胞癌（HCC）是世界上最常见的恶性肿瘤之一，通常发生于患有慢性肝病的个体。该肿瘤在男性中更为常见，其预后也比女性更差。HCC的发病机制尚不清楚。由于其明显的男性优势，雄激素已被研究为可能诱导或至少促进肝癌发生的潜在因素；这一假设也得到了雄激素在实验模型中诱导肝脏肿瘤能力的支持。另一方面，由于HCC主要发生在患有特征性激素失衡且处于相对高雌激素状态的男性肝硬化患者中，雌激素在肝癌中的潜在作用也得到了研究。本文综述了性激素在肝癌发生中的潜在作用。
