Novikov V E, Iasnetsov V V, Sharov A N
Biull Eksp Biol Med. 1992 Jul;114(8):163-5.
Opioid receptors blocker naloxone potentiated edematous effect of GABA-receptors blockers in experiments on rats. In combination with bicuculline and picrotoxine that agent leads to increased content of water in the brain and decreased brain tissue density. At the same time naloxone prevented GABA-antagonists activation of oxidative processes in brain mitochondria.
在对大鼠的实验中，阿片受体阻断剂纳洛酮增强了GABA受体阻断剂的水肿效应。与荷包牡丹碱和印防己毒素联合使用时，该药物会导致脑内水分含量增加和脑组织密度降低。同时，纳洛酮可防止GABA拮抗剂激活脑线粒体中的氧化过程。
