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[向伏隔核和黑质注射6-羟基多巴胺对大鼠行为的影响]

[The effect of 6-hydroxydopamine injections into the nucleus accumbens and substantia nigra on rat behavior].

作者信息

Saul'skaia N B

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1992 Apr;78(4):14-20.

PMID:1334857
Abstract

Bilateral infusion of 6-hydroxydophamine (15 mg/ml) into the n. accumbens and substantia nigra accelerated the avoidance conditioning and increased the dopamine and 3,4-dihydroxiphenylacetic acid levels in the striatum as compared with the rats which had only been injected the same agent in the substantia nigra alone. Infusion of this agent into the n. accumbens can be used to compensate for the nigrostriatal deficit.

摘要

向伏隔核和黑质双侧注入6-羟基多巴胺（15毫克/毫升），与仅在黑质中注射相同药物的大鼠相比，加速了回避条件反射，并提高了纹状体中多巴胺和3,4-二羟基苯乙酸的水平。将这种药物注入伏隔核可用于弥补黑质纹状体缺陷。

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[The effect of 6-hydroxydopamine injections into the nucleus accumbens and substantia nigra on rat behavior].[向伏隔核和黑质注射6-羟基多巴胺对大鼠行为的影响]
Fiziol Zh SSSR Im I M Sechenova. 1992 Apr;78(4):14-20.
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The influence of injections of 6-hydroxydopamine into the nucleus accumbens and the substantia nigra on the behavior of rats.向伏隔核和黑质注射6-羟基多巴胺对大鼠行为的影响。
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[The effect of chronic activation and block of the dopamin- and enkephalinergic systems of the neostriatum on conditioned-reflex behavior abd dopamine metabolism in the nigrostriatal system of rats].[新纹状体多巴胺能和脑啡肽能系统的慢性激活与阻断对大鼠黑质纹状体系统条件反射行为及多巴胺代谢的影响]
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Bilateral nigral 6-hydroxydopamine lesions increase the amount of extracellular dopamine in the nucleus accumbens.双侧黑质6-羟基多巴胺损伤会增加伏隔核细胞外多巴胺的含量。
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Self-injurious behavior and dopaminergic neuron system in neonatal 6-hydroxydopamine-lesioned rat: 2. Intracerebral microinjection of dopamine agonists and antagonists.新生6-羟基多巴胺损伤大鼠的自伤行为与多巴胺能神经元系统：2. 脑室内微量注射多巴胺激动剂和拮抗剂
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[Alimentary conditioned reflex behavior in the rat following injection of 6-hydroxydopamine into the caudate nucleus and nucleus accumbens].[向大鼠尾状核和伏隔核注射6-羟基多巴胺后的消化性条件反射行为]
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[The striatonigral dopaminergic system and its role in adaptive conditioned reflex behavior].[纹状体黑质多巴胺能系统及其在适应性条件反射行为中的作用]
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Differential effects of a small, unilateral, 6-hydroxydopamine-induced nigral lesion on behavior in high and low responders to novelty.小剂量单侧6-羟基多巴胺诱导的黑质损伤对新异刺激高反应者和低反应者行为的不同影响。
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Repeated D1 dopamine receptor agonist administration prevents the development of both D1 and D2 striatal receptor supersensitivity following denervation.重复给予 D1 多巴胺受体激动剂可预防去神经支配后 D1 和 D2 纹状体受体超敏反应的发生。
Synapse. 1992 Mar;10(3):206-16. doi: 10.1002/syn.890100304.

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Monoamine metabolism in the striatum of the rat brain during drug infusion into the nucleus accumbens.在向伏隔核注射药物期间大鼠脑纹状体中的单胺代谢
Neurosci Behav Physiol. 1997 Nov-Dec;27(6):728-33. doi: 10.1007/BF02461936.