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[向伏隔核和黑质注射6-羟基多巴胺对大鼠行为的影响]

[The effect of 6-hydroxydopamine injections into the nucleus accumbens and substantia nigra on rat behavior].

作者信息

Saul'skaia N B

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1992 Apr;78(4):14-20.

PMID:1334857
Abstract

Bilateral infusion of 6-hydroxydophamine (15 mg/ml) into the n. accumbens and substantia nigra accelerated the avoidance conditioning and increased the dopamine and 3,4-dihydroxiphenylacetic acid levels in the striatum as compared with the rats which had only been injected the same agent in the substantia nigra alone. Infusion of this agent into the n. accumbens can be used to compensate for the nigrostriatal deficit.

摘要

向伏隔核和黑质双侧注入6-羟基多巴胺(15毫克/毫升),与仅在黑质中注射相同药物的大鼠相比,加速了回避条件反射,并提高了纹状体中多巴胺和3,4-二羟基苯乙酸的水平。将这种药物注入伏隔核可用于弥补黑质纹状体缺陷。

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