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[多巴胺能和脑啡肽能对大鼠条件反射活动的影响之间的相关性]

[The correlation of dopamin- and enkephalinergic influences on rat conditioned-reflex activity].

作者信息

Shugalev N P, Hartman G

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1995 Sep-Oct;45(5):909-13.

PMID:8560937
Abstract

Behavioural effects of enkephalin microinjections into substantia nigra of rat brain were studied in short time after intrastriatal administration of 6-hydroxydopamine (6-OHDA). It was shown that such microinjections improved conditioned activity of animals. A conclusion was made that the role of enkephalinergic brain structures in compensatory processes in acute period of development of 6-OHDA neurotoxic action was related to increase in efficiency of the mechanisms of self-regulation of dopamine neurons.

摘要

在纹状体内注射6-羟基多巴胺（6-OHDA）后的短时间内，研究了向大鼠脑黑质微量注射脑啡肽的行为效应。结果表明，这种微量注射改善了动物的条件性活动。得出的结论是，脑啡肽能脑结构在6-OHDA神经毒性作用急性期的代偿过程中的作用与多巴胺神经元自我调节机制效率的提高有关。

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