Suvorov N F, Iakimovskiĭ A F, Saul'skaia N B
Fiziol Zh SSSR Im I M Sechenova. 1984 May;70(5):594-600.
Neurochemical and pharmacological techniques helped to study the role of the nigro-strial dophaminergic system in adaptive conditioned behaviour of rats and dogs. The avoidance technique revealed that dophamine content in the rat neostriatum increased in a more complicated task performance, and administration of 3 micrograms of dophamine into the rostral neostriatum accelerated and improved the conditioning. Nonadaptive forms of behaviour were accompanied by a drop of the dophamine level in the neostriatum. Stimulation of the caudate nucleus' dophamine-reactive system in dogs by means of administration of dophamine (60 micrograms) and phenamine led to deterioration of conditioned and unconditioned components of feeding behaviour. The effects of the dophaminomimetics were suppressed by administration of haloperidol (10 micrograms) and naloxon (0.8 micrograms) into the same area of the caudate nucleus which attested a functional interrelationship between the dophamine- and enkephalin-containing systems of the neostriatum in regulation of feeding behaviour. The data obtained and literature references gave ground for discussing the role of the nigro-strial dophaminergic system in the positive modulation of adaptive conditioned behaviour under natural conditions.
神经化学和药理学技术有助于研究黑质-纹状体多巴胺能系统在大鼠和狗的适应性条件行为中的作用。回避技术显示，在执行更复杂任务时，大鼠新纹状体中的多巴胺含量会增加，向吻侧新纹状体注射3微克多巴胺可加速并改善条件反射。非适应性行为形式伴随着新纹状体中多巴胺水平的下降。通过注射多巴胺（60微克）和苯丙胺刺激狗尾状核的多巴胺反应系统，会导致进食行为的条件反射和非条件反射成分恶化。向尾状核同一区域注射氟哌啶醇（10微克）和纳洛酮（0.8微克）可抑制多巴胺模拟物的作用，这证明新纹状体中含多巴胺系统和含脑啡肽系统在调节进食行为方面存在功能相互关系。所获得的数据和文献参考为讨论黑质-纹状体多巴胺能系统在自然条件下对适应性条件行为的正向调节作用提供了依据。
