Szelényi Z, Székely M, Romanovskiĭ A A
Fiziol Zh SSSR Im I M Sechenova. 1992 Apr;78(4):94-101.
In unanesthetized rats, the effects of intracerebroventricular injections of prostaglandin E1 (PGE1) and cholecystokinin octapeptide (CCK-8) on body temperature (Tb) regulation were studied. Both PGE1 and CCK-8 evoke hyperthermic responses of short latency and duration. Each substance raises the temperature, irrespective of initial temperature (Tbi). However, the maximal change in Tb and the rate of Tb rise depends on Tbi. A similarity of PGE1 and CCK-8 central thermoregulatory effects and putative roles of these substances in the mechanisms of fever, are discussed.
在未麻醉的大鼠中，研究了脑室内注射前列腺素E1（PGE1）和八肽胆囊收缩素（CCK-8）对体温（Tb）调节的影响。PGE1和CCK-8均引起潜伏期短和持续时间短的体温升高反应。每种物质都会升高体温，而与初始体温（Tbi）无关。然而，Tb的最大变化和Tb上升速率取决于Tbi。讨论了PGE1和CCK-8的中枢体温调节作用的相似性以及这些物质在发热机制中的假定作用。
