Matsukawa T, Kashimoto S, Matsuoka H, Takahashi M, Kumazawa T
Department of Anaesthesiology, Yamanashi Medical University, Japan.
Eur J Anaesthesiol. 1995 Jul;12(4):417-22.
Effects of prostaglandin E1 (PGE1) on temperatures during upper abdominal surgery under isoflurane anaesthesia were studied. Forty-five patients were randomly assigned to one of three groups (15 patients per group). One group received 0.05 micrograms kg-1 min-1 of PGE1, the second group received 0.1 microgram kg-1 min-1 of PGE1 just after the induction of anaesthesia, and the third group received no PGE1 during anaesthesia (control). Tympanic membrane (central) temperatures, forearm temperatures, and fingertip temperatures were recorded during surgery every 30 min. Tympanic membrane temperatures in the 0.05 micrograms kg-1 min-1 group during and at the end of surgery were significantly higher than those in the control group. In the 0.1 microgram kg-1 min-1 group, maximum decrease of tympanic membrane temperature was significantly larger than that in the control group. Fingertip temperatures in the 0.05 micrograms kg-1 min-1 group during surgery were significantly higher than those in the control group. This result suggests that 0.05 micrograms kg-1 min-1 of PGE1 may be superior to 0.1 microgram kg-1 min-1 of PGE1 for maintaining central and peripheral temperatures during surgery and general anaesthesia.
研究了前列腺素E1（PGE1）对异氟烷麻醉下上腹部手术期间体温的影响。45例患者被随机分为三组之一（每组15例患者）。一组接受0.05微克/千克/分钟的PGE1，第二组在麻醉诱导后接受0.1微克/千克/分钟的PGE1，第三组在麻醉期间不接受PGE1（对照组）。手术期间每30分钟记录鼓膜（中心）温度、前臂温度和指尖温度。0.05微克/千克/分钟组在手术期间及结束时的鼓膜温度显著高于对照组。在0.1微克/千克/分钟组中，鼓膜温度的最大降幅显著大于对照组。0.05微克/千克/分钟组在手术期间的指尖温度显著高于对照组。该结果表明，在手术和全身麻醉期间维持中心和外周体温方面，0.05微克/千克/分钟的PGE1可能优于0.1微克/千克/分钟的PGE1。
