Majewski S, Jablonska S
Department of Dermatology, Warsaw School of Medicine, Poland.
Am J Med Sci. 1992 Sep;304(3):174-9. doi: 10.1097/00000441-199209000-00006.
Epidermodysplasia verruciformis (EV) presents a genetically determined, unusual susceptibility to infection with EV-specific human papillomaviruses (HPVs) related to abrogation of immunosurveillance exclusively against these viruses. The cutaneous viral carcinogenesis depends upon potentially oncogenic HPVs, the cocarcinogenic effect of ultraviolet irradiation, and genetic host factors, presumably a defect of anti-oncogenes or alleles of major histocompatibility complex and tumor necrosis factor locus involved in antigen presentation.
疣状表皮发育不良（EV）表现出一种由基因决定的、对与仅针对这些病毒的免疫监视丧失相关的EV特异性人乳头瘤病毒（HPV）感染的异常易感性。皮肤病毒致癌作用取决于潜在致癌性HPV、紫外线照射的促癌作用以及遗传宿主因素，推测是涉及抗原呈递的抗癌基因或主要组织相容性复合体及肿瘤坏死因子基因座等位基因的缺陷。
