Pfister H
Institut für Klinische und Molekulare Virologie, Friedrich-Alexander-Universität, Erlangen, Germany.
Semin Cancer Biol. 1992 Oct;3(5):263-71.
Human papillomavirus (HPV)-induced skin warts are classically benign lesions. However an association between specific HPV types and skin cancer becomes obvious in epidermodysplasia verruciformis (EV). The analysis of this disease suggests that lesions infected with HPV types 5 and 8 carry a high risk of developing squamous cell carcinomas. The oncogenes of EV-viruses appear to be E6 and E2, rather than E7. The 'high risk' EV-viruses, HPV 5, 8, and 47, differ from related HPV types in the transforming activity of the E6 gene and in the density of positive transcription control elements in the non-coding region (NCR) of the genome. The extrachromosomal viral DNA in cancers may show deletions affecting regulatory sequences. EV-specific lesions occasionally occur in immunosuppressed patients and HPV 5 or 8 persist in some of the skin cancers to which these patients are prone. DNAs of HPV 2, 16, 34, or 41 were identified in few premalignant and malignant skin tumors of the general population.
人乳头瘤病毒（HPV）引起的皮肤疣通常是良性病变。然而，在疣状表皮发育不良（EV）中，特定HPV类型与皮肤癌之间的关联变得明显。对这种疾病的分析表明，感染HPV 5型和8型的病变发生鳞状细胞癌的风险很高。EV病毒的癌基因似乎是E6和E2，而不是E7。“高危”EV病毒，即HPV 5、8和47，在E6基因的转化活性以及基因组非编码区（NCR）中阳性转录控制元件的密度方面与相关HPV类型不同。癌症中的染色体外病毒DNA可能显示出影响调控序列的缺失。EV特异性病变偶尔发生在免疫抑制患者中，HPV 5或8型在这些患者易患的一些皮肤癌中持续存在。在普通人群的少数癌前和恶性皮肤肿瘤中鉴定出了HPV 2、16、34或41的DNA。
