Bian X W
Department of Pathology, Third Military Medical College, PLA, Chongqing.
Zhonghua Bing Li Xue Za Zhi. 1992 Jun;21(3):171-3.
The localization of S-100 protein, glial fibrillary acidic protein (GFAP) and vimentin as well as the relations between immunohistochemical reactions, grading and prognoses in 243 gliomas were investigated. In astrocytomas, both GFAP and S-100 protein were decreased along with the increase of tumor grades while the vimentin content was coincidently increased. The intensity of GFAP were negatively related to that of vimentin. Typical neoplastic oligodendroglial cells were known to be devoid of glial filaments and negative to GFAP and vimentin, anyhow, in the sporadic tumor cells, positive reaction to both GFAP and vimentin were identified, and these cells were considered to be either the astrocytes or the transitional cells between astrocytes and oligodendrocytes. Difference of the survival rates in cases with various gradings or intensities against S-100 protein and GFAP stainings were noticed. The results suggested that vimentin and GFAP may exist either independently or coexist synchronously in the astrocytomas as the markers, expressing the anaplasia stages of astrocytes. S-100 protein is considered to be an important indicator for both differentiation and prognosis of this tumor.
研究了243例胶质瘤中S-100蛋白、胶质纤维酸性蛋白（GFAP）和波形蛋白的定位，以及免疫组化反应、分级与预后之间的关系。在星形细胞瘤中，随着肿瘤分级的增加，GFAP和S-100蛋白均减少，而波形蛋白含量则相应增加。GFAP的强度与波形蛋白的强度呈负相关。典型的肿瘤性少突胶质细胞已知不含胶质丝，对GFAP和波形蛋白呈阴性，但在散在的肿瘤细胞中，发现对GFAP和波形蛋白均呈阳性反应，这些细胞被认为是星形胶质细胞或星形胶质细胞与少突胶质细胞之间的过渡细胞。注意到不同分级或S-100蛋白和GFAP染色强度的病例生存率存在差异。结果表明，波形蛋白和GFAP在星形细胞瘤中可能独立存在或同步共存，作为标记物表达星形胶质细胞的间变阶段。S-100蛋白被认为是该肿瘤分化和预后的重要指标。
