Luo X M
Guangzhou Medical College, Department of Pathology, 2nd Affiliated Hospital.
Zhonghua Bing Li Xue Za Zhi. 1993 Apr;22(2):95-7.
Seventy-four cases of human astrocytoma were studied with ABC method for GFAP and vimentin. Data indicated that all of the specimens in this series contained two different intermediate filament proteins: GFAP and vimentin. There was a negative correlation between the degree of anaplasia and the number of GFAP-positive cells, but no definite relationship was seen between the degree of anaplasia and the number of vimentin-positive cells. The ratio of V/G might be considered useful in expressing the histological differentiation of astrocytoma. Generally, two immunostainings are used in demonstrating GFAP and vimentin: one for intense perikaryo-staining and the other for cell processes. Both staining patterns are closely related to the histological type but not to the histological grade. Besides, there was a negative correlation between the cell density and the number of GFAP-positive cells.
采用ABC法对74例人类星形细胞瘤进行GFAP和波形蛋白研究。数据表明，该系列所有标本均含有两种不同的中间丝蛋白：GFAP和波形蛋白。间变程度与GFAP阳性细胞数量呈负相关，但间变程度与波形蛋白阳性细胞数量之间未见明确关系。V/G比值可能有助于表达星形细胞瘤的组织学分化。一般来说，通常使用两种免疫染色来显示GFAP和波形蛋白：一种用于强烈的核周染色，另一种用于细胞突起染色。两种染色模式均与组织学类型密切相关，但与组织学分级无关。此外，细胞密度与GFAP阳性细胞数量呈负相关。
