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[将单糖从肠上皮细胞泵过基底外侧膜的转运系统]

[The transport system that pumps monosaccharides from enterocytes across the basolateral membrane].

作者信息

Gromova L V, Ugolev A M

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1992 Aug;78(8):45-55.

PMID:1335925
Abstract

Using a new, in vitro, experimental approach the transport of glucose, galactose, fructose and glycine in seroso-mucosal direction in the small intestine, was studied under different modes of oxygenation. In case of monosaccharides under the oxygenation from serosal surface, the substrate concentration is lower in the small intestine tissue than under anoxia. The effect of the oxygenation from serosal surface on the galactose transport was shown to be sensitive to absence of sodium ions, ouabain, phloretin, and not sensitive to phlorizin. The data obtained corroborate the hypothesis of the existence of a mechanism pumping off monosaccharides enterocytes through the basolateral membrane.

摘要

采用一种新的体外实验方法,研究了在不同氧合模式下小肠中葡萄糖、半乳糖、果糖和甘氨酸在浆膜 - 黏膜方向的转运。在单糖从浆膜表面进行氧合的情况下,小肠组织中的底物浓度低于缺氧状态。浆膜表面氧合对半乳糖转运的影响表明,其对钠离子缺失、哇巴因、根皮素敏感,而对根皮苷不敏感。所得数据证实了存在一种通过基底外侧膜将单糖泵出肠上皮细胞的机制这一假说。

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