Hughes S, Smith M E, Bailey C J
Department of Physiology, Medical School, University of Birmingham, UK.
Peptides. 1992 Sep-Oct;13(5):873-7. doi: 10.1016/0196-9781(92)90043-3.
Immunoreactivity for beta-endorphin and alpha-MSH/ACTH was demonstrated in intramuscular nerves in soleus, extensor digitorum longus, and diaphragm muscles of normal and streptozotocin-diabetic mice. There was a higher incidence of immunoreactive nerves in the muscles of the diabetic mice. Specific binding for [125I]ACTH was detected in a proportion of the muscle fibers, using autoradiography. There were significantly more fibers with specific [125I]beta-endorphin sites and specific [125]ACTH sites in some muscles in the diabetic mice. The increased expression of POMC-derived peptides and their receptors in the neuromuscular system of streptozotocin-diabetic mice may indicate early neuropathic change.
在正常小鼠和链脲佐菌素诱导的糖尿病小鼠的比目鱼肌、趾长伸肌和膈肌的肌内神经中，检测到β-内啡肽和α-促黑素/促肾上腺皮质激素（ACTH）的免疫反应性。糖尿病小鼠肌肉中免疫反应性神经的发生率更高。使用放射自显影术在一部分肌纤维中检测到了[125I]ACTH的特异性结合。糖尿病小鼠的某些肌肉中，具有特异性[125I]β-内啡肽位点和特异性[125I]ACTH位点的纤维明显更多。链脲佐菌素诱导的糖尿病小鼠神经肌肉系统中阿片促黑激素皮质素原衍生肽及其受体表达的增加可能表明早期神经病变。
