Smith M E, Hughes S
Department of Physiology, Medical School, University of Birmingham, UK.
Mol Chem Neuropathol. 1993 May-Jun;19(1-2):137-45. doi: 10.1007/BF03160174.
Autoradiography was used to investigate the presence of corticotropin and beta-endorphin receptors on soleus, extensor digitorum longus, and diaphragm muscles of normal and dystrophic adult mice and developing mice. In both adult and developing mice, specific binding sites for both [125I]ACTH and [125I]beta-endorphin were present in some fibers in all of the muscles examined. The specific binding sites appeared to be distributed over the length of the surface membrane in the fibers that expressed them. There were significantly higher proportions of fibers exhibiting the specific beta-endorphin and the specific ACTH binding sites in the three muscle types in mice of 5 d of age compared to the muscles of the normal adult. There was also a higher proportion of fibers with the putative ACTH and beta-endorphin receptors in the three muscle types in dystrophic mice.
利用放射自显影技术研究正常和营养不良成年小鼠及发育中小鼠的比目鱼肌、趾长伸肌和膈肌上促肾上腺皮质激素和β-内啡肽受体的存在情况。在成年和发育中的小鼠中，在所检查的所有肌肉的一些纤维中均存在[125I]促肾上腺皮质激素和[125I]β-内啡肽的特异性结合位点。特异性结合位点似乎分布在表达它们的纤维表面膜的长度上。与正常成年小鼠的肌肉相比，5日龄小鼠的三种肌肉类型中显示特异性β-内啡肽和特异性促肾上腺皮质激素结合位点的纤维比例明显更高。在营养不良小鼠的三种肌肉类型中，具有假定促肾上腺皮质激素和β-内啡肽受体的纤维比例也更高。
