Knezević-Usaj S, Marković-Lipkovski J, Jovanović R
Vojnomedicinska akademija, Institut za patologiju i sudsku medicinu.
Vojnosanit Pregl. 1992 Sep-Oct;49(5):432-8.
In order to assess frequency and importance of the presence of alpha fetoprotein (AFP) and AlAChy as well as hepatitis B virus (HBV) infection antigens in the tissue of hepatocellular carcinoma (HCC) and in the liver tissue outside a tumour, there have been performed retrospective light-microscopic and immunohistochemical examinations of the liver tissue in 65 cases of HCC (39 autopsy and 26 biopsy cases). The finding of AlAChy in 100% of autopsy cases of HCC and 80.7% of biopsy cases of HCC compared with the presence of AFP in 33% of autopsy and 61.5% of biopsy cases point out that AlAChy is a more sensitive marker than AFP in diagnosing HCC. The presence of HBV infection antigens in 43.5% of autopsy cases and 23.5% of biopsy cases of HCC point to an important role of HBV infection in development of HCC in the studied population.
为了评估甲胎蛋白（AFP）、AlAChy以及乙肝病毒（HBV）感染抗原在肝细胞癌（HCC）组织和肿瘤外肝组织中的出现频率及重要性，对65例HCC患者（39例尸检和26例活检病例）的肝组织进行了回顾性光学显微镜和免疫组化检查。在100%的HCC尸检病例和80.7%的HCC活检病例中发现了AlAChy，相比之下，AFP在33%的尸检病例和61.5%的活检病例中出现，这表明在诊断HCC方面，AlAChy是比AFP更敏感的标志物。43.5%的HCC尸检病例和23.5%的HCC活检病例中存在HBV感染抗原，这表明HBV感染在所研究人群的HCC发生过程中起重要作用。
