通过人脑质子局部核磁共振波谱对神经疾病进行代谢特征分析。

Metabolic characterization of neurological diseases by proton localized NMR spectroscopy of the human brain.

作者信息

Confort-Gouny S, Vion-Dury J, Nicoli F, Dano P, Gastaut J L, Cozzone P J

机构信息

Centre de Résonance magnétique biologique et médicale, U.R.A.-C.N.R.S. n. 1186, Faculté de Médecine, Marseille.

出版信息

C R Acad Sci III. 1992;315(7):287-93.

PMID:1336428

Abstract

Proton localized Magnetic Resonance Spectroscopy (MRS) of the brain allows the non invasive detection of intracellular cerebral metabolites. Localized MRS has been performed using short stimulated-echo times in various neurological diseases including stroke, multiple sclerosis, and AIDS-related leukoencephalopathies. Principal component analysis (PCA) was used to determine the critical parameters defining the metabolic profile of normal and diseased brain. PCA clearly differentiates the demyelinating processes from ischaemic lesions and leukoencephalopathies. Localized MRS of the brain appears growingly as a tool of choice to discriminate, quantitate and assess cerebral metabolic damage in patients with neurological disorders.

摘要

脑部质子局部磁共振波谱（MRS）能够对细胞内脑代谢物进行无创检测。在包括中风、多发性硬化症和艾滋病相关性白质脑病在内的各种神经系统疾病中，已使用短刺激回波时间进行局部MRS检查。主成分分析（PCA）用于确定定义正常和患病脑部代谢特征的关键参数。PCA能够清晰地区分脱髓鞘过程与缺血性病变和白质脑病。脑部局部MRS越来越成为鉴别、定量和评估神经系统疾病患者脑代谢损伤的首选工具。