Silman A J, Jones S
Arthritis and Rheumatism Council, Epidemiology Research Unit, University of Manchester, United Kingdom.
Ann Rheum Dis. 1992 Dec;51(12):1322-4. doi: 10.1136/ard.51.12.1322.
An occupational analysis of 56 men with scleroderma in the United Kingdom showed no evidence that silica exposure was implicated in the onset of the disease, in contrast with older published reports suggesting that such exposure explained an important proportion of the occurrence of the disease in men. Of the major occupational exposures suggested from case reports, only organic solvents were reported to any extent in this series. No significant increase in exposure to organic solvents was noted, however, in a case control analysis.
对英国56名硬皮病男性患者进行的职业分析表明，没有证据表明二氧化硅暴露与该病的发病有关，这与早期发表的报告相反，早期报告表明这种暴露解释了男性中该病发生的很大一部分比例。在病例报告中提出的主要职业暴露中，本系列中仅在一定程度上报告了有机溶剂。然而，在病例对照分析中，未发现有机溶剂暴露有显著增加。
