Betta A, Tommasini M, Bovenzi M, Barbone F, Versini W, Romeo L
Istituto di Medicina del Lavoro, Università di Trieste.
Med Lav. 1994 Nov-Dec;85(6):496-506.
The scientific literature concerning occupational factors associated with scleroderma consists mostly of case report type studies. We therefore undertook a case-control study in the Province of Trento using as data source the Hospital Records System. The annual rate of scleroderma incidence in the period considered (1976-1991) was 5.8 per million in females and 1.5 per million in males. A statistically significant association was observed (OR = 9.28, p = 0.039) in the population under study for occupational exposure to solvents. Also, an excess risk was observed in male subjects exposed to silica dust, even though the simultaneous exposure to other risk factors, such as hand-arm vibrations, makes it difficult to establish the specific contribution of silica dust exposure.
有关与硬皮病相关职业因素的科学文献大多是病例报告类研究。因此，我们在特伦托省利用医院记录系统作为数据源进行了一项病例对照研究。在研究期间（1976 - 1991年），硬皮病的年发病率女性为每百万5.8例，男性为每百万1.5例。在所研究的人群中，观察到职业性接触溶剂存在统计学显著关联（比值比 = 9.28，p = 0.039）。此外，在接触二氧化硅粉尘的男性受试者中也观察到了额外风险，尽管同时接触其他风险因素，如手臂振动，使得难以确定二氧化硅粉尘接触的具体作用。
