Uhl G R
Johns Hopkins University School of Medicine, Baltimore, MD 21224.
NIDA Res Monogr. 1992;126:14-22.
Studies of the two neurotransmitter receptor genes described here illustrate the rich possibilities that this area of molecular neurobiology holds for drug abuse research. Since many of the 100 to 150 different neurotransmitters could have multiple receptor genes, as many as 1,000 different genes or 1 percent of the human genome might encode neurotransmitter receptors. Clearly, as the other chapters in this monograph also indicate, the field is ripe with possibilities of discovery with implications for drug action.
此处所描述的对两种神经递质受体基因的研究表明,分子神经生物学的这一领域为药物滥用研究提供了丰富的可能性。由于100到150种不同神经递质中的许多可能具有多个受体基因,多达1000种不同的基因,即人类基因组的1%,可能编码神经递质受体。显然,正如本专著中的其他章节也表明的那样,该领域充满了发现的可能性,对药物作用具有重要意义。