Joffe P, Ladefoged S D, Cintin C, Lehmann H
Department of Nephrology, Herlev County Hospital, Denmark.
Nephrol Dial Transplant. 1992;7(12):1249-51. doi: 10.1093/ndt/7.12.1249.
The present study examines the adsorptive phenomenon of 1 alpha-hydroxycholecalciferol (1 alpha-OHD3) to peritoneal dialysis bags. One minute after injection of 1 alpha-OHD3 into the dialysis bags, a significant adsorption to the bags was observed in experiments where albumin was not added. A higher temperature (37 degrees versus 23 degrees C) in bags containing 13.6 mg glucose/ml resulted in less adsorption (P < 0.05). Adding albumin to bags at 37 degrees C with a glucose concentration of 13.6 mg/ml, reduced the adsorptive phenomenon significantly (P < 0.01). Bags tested at 37 degrees C with a glucose concentration of 38.6 mg/ml resulted in a significantly higher 1 alpha-OHD3 adsorption than bags containing 13.6 mg glucose/ml (P < 0.01). It is concluded that adsorption of 1 alpha-OHD3 to dialysis bags is affected by time, albumin, temperature and glucose concentrations. Substantial amounts of 1 alpha-OHD3 is retained by the peritoneal dialysis system when albumin is not added.
本研究考察了1α-羟基胆钙化醇（1α-OHD3）在腹膜透析袋上的吸附现象。向透析袋中注入1α-OHD3一分钟后，在未添加白蛋白的实验中观察到透析袋对其有显著吸附。在含有13.6mg葡萄糖/毫升的透析袋中，较高温度（37℃对比23℃）导致吸附减少（P<0.05）。在37℃且葡萄糖浓度为13.6mg/毫升的透析袋中添加白蛋白，可显著降低吸附现象（P<0.01）。在37℃且葡萄糖浓度为38.6mg/毫升的条件下测试的透析袋，其1α-OHD3吸附量显著高于含有13.6mg葡萄糖/毫升的透析袋（P<0.01）。得出结论，1α-OHD3在透析袋上的吸附受时间、白蛋白、温度和葡萄糖浓度的影响。当不添加白蛋白时，腹膜透析系统会保留大量的1α-OHD3。
