Kumar L, Bhargava V L, Rao R C, Rath G K, Kataria S P
Department of Medical Oncology, All India Institute of Medical Sciences, New Delhi.
Asia Oceania J Obstet Gynaecol. 1992 Dec;18(4):309-13. doi: 10.1111/j.1447-0756.1992.tb00324.x.
Bone involvement in carcinoma of ovary occurs rarely. In a review of 103 patients over last 3 years we have seen 4 such patients (serous-2, mucinous-1, mixed germ cell tumour-1). Patients presented with severe localized bone pain, bony swelling and difficulty in walking. The common sites of involvement were vertebrae, pelvic bones and skull. Radiologically the osteolytic lesions were commonest. Bone lesions were associated with abdomino-pelvic disease in 3 patients. Cisplatinum based chemotherapy in addition to local radiation resulted in significant response in 2 patients; one complete and one partial response. The median survival was 7.5 months (range 6-39 months) after bone metastasis. We conclude bone involvement in cancer ovary is associated with poor prognosis.
卵巢癌发生骨转移的情况很少见。在过去3年对103例患者的回顾中，我们发现了4例这样的患者（浆液性癌2例、黏液性癌1例、混合性生殖细胞肿瘤1例）。患者表现为严重的局部骨痛、骨肿胀和行走困难。常见的受累部位是椎骨、骨盆骨和颅骨。放射学检查显示溶骨性病变最为常见。3例患者的骨病变与腹盆腔疾病相关。除局部放疗外，基于顺铂的化疗使2例患者有显著反应；1例完全缓解，1例部分缓解。骨转移后的中位生存期为7.5个月（范围6 - 39个月）。我们得出结论，卵巢癌发生骨转移与预后不良相关。
