Department of Mother and Child Medicine, "Grigore. T. Popa" University of Medicine and Pharmacy, 700115 Iaşi, Romania.
Department of Morphofunctional Sciences I, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iaşi, Romania.
Medicina (Kaunas). 2021 May 27;57(6):534. doi: 10.3390/medicina57060534.
Ovarian malignant germ cell tumors (OMGCT) represent less than 10% of all ovarian tumors. Dysgerminoma is the most common malignant primitive germ cell tumor in young women, known for its curability and low propensity to invade and metastasize when diagnosed early. Herein, we report an unusual type of ovarian dysgerminoma (OD) metastasis with a brief review of the literature, lacking similar reported cases. To our knowledge, although there are several case reports of dysgerminoma metastases with variable anatomic location and presentation, vaginal metastasis has not been previously described. The local or systemic relapse together with local and distant metastasis is considered as an independent predictor of poor survival in patients with OD. In light of the absence of mutations status, our patient successfully responded to therapy. Currently, the patient remains in clinical remission. A specific follow-up plan is ongoing knowing that ovarian dysgerminomas tend to recur most often in the first 2-3 years after treatment.
卵巢恶性生殖细胞肿瘤(OMGCT)占所有卵巢肿瘤的比例不到 10%。卵黄囊瘤是年轻女性最常见的恶性原始生殖细胞肿瘤,其特点是早期诊断时具有可治愈性和低侵袭性及转移性。在此,我们报告了一种罕见的卵巢卵黄囊瘤(OD)转移类型,并简要回顾了文献,未发现类似的报道病例。据我们所知,尽管有几例报道的卵黄囊瘤转移具有不同的解剖位置和表现,但阴道转移尚未被描述过。局部或全身复发以及局部和远处转移被认为是 OD 患者生存不良的独立预测因素。鉴于没有突变状态,我们的患者对治疗有反应。目前,患者仍处于临床缓解期。由于卵巢卵黄囊瘤在治疗后 2-3 年内最常复发,因此正在进行特定的随访计划。