Yamamoto T, Shimura T, Sako N, Azuma S, Bai W Z, Wakisaka S
Department of Behavioural Physiology, Faculty of Human Sciences, Osaka University, Japan.
Neuroreport. 1992 Dec;3(12):1049-52. doi: 10.1097/00001756-199212000-00004.
The distribution of evoked expression of the proto-oncogene c-fos was immunohistochemically examined in the rat brain after intraperitoneal injection of isotonic LiCl, which is commonly used to induce internal malaise in the conditioned taste aversion paradigm. C-fos-like immunoreactive neurones (c-fos neurones) were most densely observed in the central amygdaloid nucleus, external lateral subnucleus of the parabrachial nucleus (PBN), posteromedial and commissural parts of the nucleus of the tractus solitarius (NTS) and area postrema (AP). Experiments including vagotomy, intravenous injection of LiCl and lesions of the area postrema suggest that NTS neurones are activated via both sides of the vagus nerves, while AP neurones, humorally as well as neurally via the vagal nerve with a right side predominance. The activated NTS and AP neurones project mainly to the external lateral subnucleus of the PBN and lightly to the central lateral subnucleus of the PBN. These results are discussed in terms of the role of LiCl in the formation of conditioned taste aversion.
腹腔注射等渗氯化锂后，采用免疫组织化学方法检测大鼠脑中原癌基因c-fos诱发性表达的分布情况。氯化锂常用于条件性味觉厌恶范式中诱发体内不适。在杏仁中央核、臂旁核外侧亚核、孤束核后内侧和连合部以及最后区观察到最密集的c-fos样免疫反应性神经元（c-fos神经元）。包括迷走神经切断术、静脉注射氯化锂和最后区损伤在内的实验表明，孤束核神经元通过双侧迷走神经激活，而最后区神经元则通过体液以及通过迷走神经以右侧为主的神经方式激活。激活的孤束核和最后区神经元主要投射到臂旁核外侧亚核，少量投射到臂旁核中央外侧亚核。根据氯化锂在条件性味觉厌恶形成中的作用对这些结果进行了讨论。
