Engfeldt P, Linde B
Department of Family Medicine, Huddinge Hospital, Sweden.
Int J Obes Relat Metab Disord. 1992 Nov;16(11):875-9.
Subcutaneous adipose tissue blood flow (ATBF) was measured by the local clearance of 133Xe from the abdominal and femoral regions of nine individuals with non-endocrine obesity before and after seven days of fasting. Fifteen non-obese individuals served as controls. In the obese group ATBF was similar in the abdominal and femoral regions, 1.7 +/- 0.2 and 1.8 +/- 0.2 ml/min/100 g adipose tissue, respectively. In contrast, in the non-obese group the abdominal ATBF was higher, 4.1 +/- 0.6 and 2.4 +/- 0.2 ml/min/100 g adipose tissue, respectively (P < 0.01). During fasting, ATBF in the abdominal region increased by 45% (P < 0.01), but it remained unchanged in the femoral region. The mechanisms behind the differences in responses to fasting in the two regions are unsettled but may depend on regional differences in lipolytic activity and responses to vasoactive substances. Furthermore, the vasodilator response to fasting in the abdominal region in combination with the higher lipolytic rate in that region may be a pathophysiological factor behind the increased cardiovascular morbidity associated with abdominal obesity.
通过测量9名非内分泌性肥胖个体在禁食7天前后腹部和股部区域对133Xe的局部清除率，来测定皮下脂肪组织血流量（ATBF）。15名非肥胖个体作为对照。在肥胖组中，腹部和股部区域的ATBF相似，分别为1.7±0.2和1.8±0.2毫升/分钟/100克脂肪组织。相比之下，在非肥胖组中，腹部ATBF较高，分别为4.1±0.6和2.4±0.2毫升/分钟/100克脂肪组织（P<0.01）。在禁食期间，腹部区域的ATBF增加了45%（P<0.01），但股部区域的ATBF保持不变。两个区域对禁食反应差异背后的机制尚不清楚，但可能取决于脂解活性和对血管活性物质反应的区域差异。此外，腹部区域对禁食的血管舒张反应与该区域较高的脂解率相结合，可能是与腹部肥胖相关的心血管发病率增加背后的病理生理因素。
