Markel' A L, Shishkina G T
Genetika. 1992 Nov;28(11):130-3.
Arterial blood pressure reactivity to the emotional stress and brain alpha 1-adrenoreceptors concentrations were studied in hypertensive (ISIAH strain) and normotensive (Wistar strain) rats and their F1 and F2 hybrids. Significant correlations between the stress-induced increase in the arterial blood pressure and the amount of alpha 1-adrenoreceptors in hypothalamus (+0.46) and medulla (+0.38) were found in the F2. This cosegregation may point to the significant role of genetically determined peculiarities of expression of alpha 1-adrenoreceptors in brain regions during pathogenesis of arterial hypertension in the ISIAH strain.
研究了高血压（ISIAH品系）和正常血压（Wistar品系）大鼠及其F1和F2杂种对情绪应激的动脉血压反应性和脑α1-肾上腺素能受体浓度。在F2代中发现，应激诱导的动脉血压升高与下丘脑（+0.46）和延髓（+0.38）中α1-肾上腺素能受体的数量之间存在显著相关性。这种共分离可能表明，在ISIAH品系动脉高血压发病机制中，脑区α1-肾上腺素能受体表达的遗传决定特性具有重要作用。
