仙台病毒引起的肺炎期间的急性呼吸衰竭

Acute respiratory failure during pneumonia induced by Sendai virus.

作者信息

van Daal G J, Eijking E P, So K L, Fievez R B, Sprenger M J, van Dam D W, Erdmann W, Lachmann B

机构信息

Dept of Anesthesiology, Erasmus University Rotterdam, The Netherlands.

出版信息

Adv Exp Med Biol. 1992;316:319-26. doi: 10.1007/978-1-4615-3404-4_37.

DOI:10.1007/978-1-4615-3404-4_37

PMID:1337653

Abstract

In this study a model of acute respiratory failure due to viral pneumonia in rats, closely resembling ARDS, is presented. Severe respiratory failure with lethal outcome in four days was induced by infection concentrated Sendai virus aerosol. This model permits evaluation of different therapeutical approaches for improving gas exchange during ARDS. Furthermore, preliminary results of surfactant substitution therapy in this model are presented.

摘要

本研究提出了一种大鼠病毒性肺炎所致急性呼吸衰竭模型，该模型与急性呼吸窘迫综合征（ARDS）极为相似。通过雾化吸入浓缩仙台病毒诱发严重呼吸衰竭，4天内导致死亡。该模型可用于评估改善ARDS期间气体交换的不同治疗方法。此外，还介绍了该模型中表面活性剂替代疗法的初步结果。