Zeng C X, Fu X S
Jiangxi Medical College, Nanchang.
Zhonghua Bing Li Xue Za Zhi. 1992 Oct;21(5):305-7.
Preliminary observation on immunocytochemical localization of anti-HCG and anti-HPL in 49 patients with gestational trophoblastic neoplasms was studied. The findings were; (1) staining patterns to the two antibodies were different in cytotrophoblasts (CT), intermediate trophoblasts (IT), and syncytiotrophoblasts (ST) of the different types of trophoblastic tumor, (2)STs in tumors of all patients except one, showed positive staining of anti-HCG, and ITs in 17 cases of HM, 10 cases of IM and 1 case of GC were stained positively for anti-HCG; (3)STs in all of the 29 cases of HM, 14 cases of IM and 1 case of GC were positive for anti-HPL, ITs in 22 cases of HM, 11 cases of IM and 2 cases of GC were stained positively for anti-HPL. CTs in all tumors of the 49 patients were devoid of HCG and HPL. The results indicated that the production of HPL was found in well-differentiated cells and HCG in undifferentiated cells. The prognostic value of immunocytochemical localization of the two antibodies in trophoblastic tumors needs to be further clarified.
对49例妊娠滋养细胞肿瘤患者进行抗人绒毛膜促性腺激素（anti-HCG）和抗人胎盘催乳素（anti-HPL）免疫细胞化学定位的初步观察。结果如下：（1）不同类型滋养细胞肿瘤的细胞滋养层（CT）、中间型滋养层（IT）和合体滋养层（ST）对两种抗体的染色模式不同；（2）除1例患者外，所有患者肿瘤中的ST均显示anti-HCG阳性染色，17例完全性葡萄胎（HM）、10例侵袭性葡萄胎（IM）和1例绒毛膜癌（GC）中的IT对anti-HCG呈阳性染色；（3）29例HM、14例IM和1例GC中的所有ST对anti-HPL呈阳性，22例HM、11例IM和2例GC中的IT对anti-HPL呈阳性染色。49例患者所有肿瘤中的CT均未检测到HCG和HPL。结果表明，HPL在分化良好的细胞中产生，而HCG在未分化细胞中产生。两种抗体在滋养细胞肿瘤中的免疫细胞化学定位的预后价值有待进一步阐明。
