Zeng C X, Fu X S
Jiangxi Medical College, Nanchang.
Zhonghua Fu Chan Ke Za Zhi. 1991 May;26(3):155-7, 188.
Preliminary observations on immunocytochemical localization of human chorionic gonadotropin (hCG) and human placental lactogen (hPL) were made in 35 placentae of normal pregnancy at various stages of development. By analysing the processing regularities of the two hormones and comparing the characteristics of immunocytochemical localization and hematoxylin-eosin stain on various trophoblasts in the normal placentae, the findings showed: (1) presence of the three types of trophoblasts, namely, cytotrophoblast (CT), intermediate trophoblast (IT), and syncytiotrophoblast (ST) was confirmed in normal placentae of first-trimester pregnancy. (2) IT has distinctive immunocytochemical features that distinguishes itself from CT and ST. In the first-trimester, ST contains a large amount of hCG which sharply diminishes thereafter, but hPL in ST increases with the fetal age. IT contains hPL all through the pregnancy period and the peak-value occurs in the second trimester. CT is devoid of hCG and hPL. The results indicated: (1) IT is more like ST but different from CT. (2) IT contains chiefly hPL and hCG only locally in early pregnancy which demonstrates that the processing of hPL is in the more well differentiated cells whereas hCG is in the less differentiated cells.
对35例处于不同发育阶段的正常妊娠胎盘进行了人绒毛膜促性腺激素（hCG）和人胎盘催乳素（hPL）免疫细胞化学定位的初步观察。通过分析这两种激素的加工规律，并比较正常胎盘不同滋养层细胞的免疫细胞化学定位特征和苏木精-伊红染色特征，结果显示：（1）在妊娠早期的正常胎盘中证实存在三种类型的滋养层细胞，即细胞滋养层（CT）、中间滋养层（IT）和合胞体滋养层（ST）。（2）IT具有独特的免疫细胞化学特征，使其有别于CT和ST。在妊娠早期，ST含有大量hCG，此后急剧减少，但ST中的hPL随胎龄增加。IT在整个孕期都含有hPL，峰值出现在妊娠中期。CT不含hCG和hPL。结果表明：（1）IT更像ST但不同于CT。（2）IT主要含有hPL，仅在妊娠早期局部含有hCG，这表明hPL在分化程度较高的细胞中加工，而hCG在分化程度较低的细胞中加工。
