胺碘酮对大鼠血液学及红细胞膜的影响
Haematological and erythrocyte membrane changes induced by amiodarone, in rats.
作者信息
Padmavathy B, Devraj N S, Devraj H
机构信息
Department of Biochemistry, University of Madras.
出版信息
Indian J Physiol Pharmacol. 1992 Oct;36(4):276-8.
The effect of Amiodarone (AD), a cationic amphiphilic drug, on erythrocytes and leucocytes was studied. Treatment of rats with AD showed a significant decrease in the red cell count and the level of Hemoglobin. Amiodarone altered the fluidity of the erythrocyte membrane followed by a decrease in the activities of membrane bound enzymes like (Na+, K+)-ATPase, Acetylcholine esterase and NADH dehydrogenase. A slight increase in the leucocyte count was also observed in the treated animals.
研究了阳离子两亲性药物胺碘酮（AD）对红细胞和白细胞的影响。用AD处理大鼠后，红细胞计数和血红蛋白水平显著降低。胺碘酮改变了红细胞膜的流动性，随后膜结合酶如（Na +，K +）-ATP酶、乙酰胆碱酯酶和NADH脱氢酶的活性降低。在接受治疗的动物中还观察到白细胞计数略有增加。
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