氯仿 - 铁螯合物在离体坐骨神经中形成脂过氧化物。
Formation of lipoperoxide in isolated sciatic nerve by chinoform-ferric chelate.
作者信息
Yagi Y, Matsuda M, Yagi K
出版信息
Experientia. 1976;32(7):905-6. doi: 10.1007/BF02003759.
PMID:133813
Abstract
Effects of chinoform and chinoform-ferric chelate on formation of lipoperoxide in isolated sciatic nerve were investigated. Free chinoform did not increase the lipoperoxide level, while chinoform-ferric chelate significantly increased it. Assuming that the lipoperoxide formed denatures the associated protein in the nerve, the effect of chinoform-ferric chelate could explain, at least partly, the demyelination of nerve tissues caused by massive doses of chinoform.
摘要
研究了氯仿及氯仿-铁螯合物对离体坐骨神经中脂质过氧化物形成的影响。游离氯仿并未增加脂质过氧化物水平，而氯仿-铁螯合物则显著增加了该水平。假设所形成的脂质过氧化物使神经中的相关蛋白质变性，那么氯仿-铁螯合物的作用至少可以部分解释大剂量氯仿所致神经组织的脱髓鞘现象。
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