Singh J, Ravi R N, Dutta A K, Kumari S, Khare S
Department of Pediatrics, Lady Hardinge Medical College, New Delhi.
Indian Pediatr. 1992 Nov;29(11):1353-6.
Fifty two children were immunized with two doses of enhanced potency inactivated polio vaccine in order to determine its efficacy. The vaccine was very efficacious with 92.3, 92.3 and 88.3% of the children seroconverting to the three poliovirus types, respectively. The vaccine was equally efficacious whether the two doses were given at 4-week or 8-week intervals or when immunization was started at 6-7 weeks of age or later. The presence of maternal antibodies did not interfere significantly with the seroresponse to two doses of IPV-E. The study recommends that two doses of IPV-E give satisfactory seroconversion rates. Immunization can be started as early as 6 weeks age and the two doses can be given at 4 weeks interval to complete primary immunization against poliomyelitis.
为确定其效力，对52名儿童接种了两剂高效灭活脊髓灰质炎疫苗。该疫苗非常有效，分别有92.3%、92.3%和88.3%的儿童对三种脊髓灰质炎病毒型产生了血清转化。无论两剂疫苗是间隔4周还是8周接种，或者免疫接种是在6至7周龄或更大年龄开始，该疫苗的效力都是相同的。母源抗体的存在并未显著干扰对两剂高效灭活脊髓灰质炎疫苗的血清反应。该研究建议，两剂高效灭活脊髓灰质炎疫苗能产生令人满意的血清转化率。免疫接种可早在6周龄开始，两剂疫苗可间隔4周接种，以完成针对脊髓灰质炎的基础免疫。
