Fülöp E
Dermatologica. 1976;152 Suppl 1:139-46. doi: 10.1159/000257875.
Different hydrocortisone microcrystal suspensions applied intradermally in rabbits caused skin atrophy. This could be ascribed to secondary tissue degeneration as was ascertained histologically. The degree of degeneration was related to the concentration of the suspension, size of the microcrystals and frequency of the intervals between the injections. The ground substance of the connective tissue changes and is characterized by a basophilic granular mass, homogenized collagen fibers and degeneration of the elastic fibers. The pathomechanism of local skin atrophy not only differs from connective tissue degeneration caused by systemic corticosteroid treatment but also from the degeneration caused by topical treatment.
给兔子皮内注射不同的氢化可的松微晶混悬液会导致皮肤萎缩。组织学检查确定，这可能归因于继发性组织变性。变性程度与混悬液浓度、微晶大小以及注射间隔频率有关。结缔组织的基质发生变化，其特征为嗜碱性颗粒物质、均质化的胶原纤维和弹性纤维变性。局部皮肤萎缩的发病机制不仅不同于全身皮质类固醇治疗引起的结缔组织变性，也不同于局部治疗引起的变性。
