Gomez E C, Berman B, Miller D L
J Dermatol Surg Oncol. 1982 Dec;8(12):1071-4. doi: 10.1111/j.1524-4725.1982.tb01097.x.
A noninvasive technique of pulsed ultrasound was used to determine the long-term changes in skin thickness resulting from intradermal injections of triamcinolone acetonide (TA). Injections of 0.1 ml of either saline or a suspension containing 5 mg/ml or 10 mg/ml of TA were made at selected sites on the forearms of two human volunteers. The corticosteroid-treated sites showed a maximal decrease of 30% to 40% of the original skin thickness at 4 to 8 weeks after a single injection. A transient thinning was observed at control sites injected with saline. A greater degree of thinning was seen at the site injected with 10 mg/ml of TA as compared to the site injected with 5 mg/ml of TA. The thinning at the corticosteroid injection sites persisted at least 18 weeks after the single corticosteroid injection but had approached normal thickness values by 44 weeks following treatment. Pulsed ultrasound may be useful as a noninvasive technique for monitoring the effects of intradermally injected corticosteroids on human skin thickness and may also be useful in assessing intrinsic atrophogenic potentials of different corticosteroid molecules in human skin and the duration of action of various injectable formulations of a corticosteroid.
采用脉冲超声无创技术来确定皮内注射曲安奈德（TA）后皮肤厚度的长期变化。在两名人类志愿者的前臂选定部位注射0.1毫升生理盐水或含有5毫克/毫升或10毫克/毫升TA的混悬液。单次注射后4至8周，皮质类固醇治疗部位的皮肤厚度较原始厚度最大减少30%至40%。在注射生理盐水的对照部位观察到短暂变薄。与注射5毫克/毫升TA的部位相比，注射10毫克/毫升TA的部位变薄程度更大。单次注射皮质类固醇后，皮质类固醇注射部位的变薄至少持续18周，但治疗后44周已接近正常厚度值。脉冲超声作为一种无创技术，可能有助于监测皮内注射皮质类固醇对人体皮肤厚度的影响，也可能有助于评估不同皮质类固醇分子在人体皮肤中的内在萎缩潜能以及各种皮质类固醇注射制剂的作用持续时间。
