Golden P, Baird L, Malaisse W J, Malaisse-Lagae F, Walker M M
Diabetologia. 1976 Jul;12(3):207-9. doi: 10.1007/BF00422087.
The present experiments were designed to compare the effects of streptozotocin and 1-methyl-1-nitrosourea upon glucose-induced insulin secretion by isolated islets of Langerhans. Both drugs depressed the insulin response at one and two hours incubation but higher molar concentrations of the nitrosourea were required to produce the same level of inhibition as streptozotocin, a difference perhaps related to the latter's glucose moiety.
本实验旨在比较链脲佐菌素和1-甲基-1-亚硝基脲对分离的胰岛葡萄糖诱导的胰岛素分泌的影响。在孵育1小时和2小时时，两种药物均降低了胰岛素反应，但需要更高摩尔浓度的亚硝基脲才能产生与链脲佐菌素相同程度的抑制，这种差异可能与链脲佐菌素的葡萄糖部分有关。
