种子提取物对链脲佐菌素对大鼠胰岛葡萄糖刺激的胰岛素释放和葡萄糖稳态的有害作用的保护作用。
Protective action of seed extracts against the deleterious effect of streptozotocin on both glucose-stimulated insulin release from rat pancreatic islets and glucose homeostasis.
作者信息
Benariba Nabila, Bellakdhar Wafaa, Djaziri Rabeh, Hupkens Emeline, Louchami Karim, Malaisse Willy J
机构信息
Laboratory of Antibiotic and Antifungal Physico-Chemistry, Synthesis and Biological Activity, Faculty of Sciences, University Abou Bekr Belakaïd, Tlemcen, Algeria ; ; Laboratory of Experimental Hormonology, Free University of Brussels, Brussels, Belgium.
Laboratory of Antibiotic and Antifungal Physico-Chemistry, Synthesis and Biological Activity, Faculty of Sciences, University Abou Bekr Belakaïd, Tlemcen, Algeria ;
出版信息
Biomed Rep. 2013 Jan;1(1):119-121. doi: 10.3892/br.2012.5. Epub 2012 Aug 27.
extracts improve glucose homeostasis in alloxan- or streptozotocin (STZ)-induced diabetic rats. Little is known, however, regarding the protective effect of these extracts against the β-cytotoxic action of STZ. In the present study, an HO-methanol extract was found to suppress the inhibition of glucose-stimulated insulin secretion by STZ in rat-isolated pancreatic islets. Similarly, when an aqueous extract from seeds was injected daily for 21 days prior to STZ administration, the perturbation of glucose homeostasis otherwise generated by the β-cytotoxic agent was minimized in rats.
提取物可改善四氧嘧啶或链脲佐菌素（STZ）诱导的糖尿病大鼠的葡萄糖稳态。然而，关于这些提取物对STZ的β细胞毒性作用的保护作用知之甚少。在本研究中，发现一种HO-甲醇提取物可抑制STZ对大鼠分离胰岛中葡萄糖刺激的胰岛素分泌的抑制作用。同样，在给予STZ之前，每天注射种子水提取物21天，可使β细胞毒性剂原本产生的葡萄糖稳态紊乱在大鼠中降至最低。
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