Chen S L
Department of Rheumatology, Ren Ji Hospital, Shanghai.
Zhonghua Yi Xue Za Zhi. 1992 Sep;72(9):534-7, 573.
The maternal and fetal outcome in 20 patients with lupus erythematosus in pregnancy was studied prospectively. The conditions of the patients were: remission in 4 patients, inactive (controlled by 10 mg prednisone for at least 6 months) 11, active 5 (active disease while pregnancy 3 and first onset and diagnosis during pregnancy 2). There were no maternal death, fetal loss or still birth in full pregnancy course. But the intrauterine malnutrition, low placenta weight and low body weight of newborns were significantly associated with active maternal disease (P < 0.001, P < 0.05). We conclude that (1) family planning pregnancy should be planned in a period while the active disease has been well controlled with a small dose of corticosteroids for at least 6 months. (2) carefully monitoring of the disease activity at intra- and post-partum is essential to lupus patient for a successful birth.
对20例妊娠合并红斑狼疮患者的母婴结局进行了前瞻性研究。患者情况如下：4例缓解期，11例非活动期（用10毫克泼尼松控制至少6个月），5例活动期（妊娠期间疾病活动3例，妊娠期间首次发病并诊断2例）。整个孕期无孕产妇死亡、胎儿丢失或死产情况。但新生儿宫内营养不良、胎盘重量低和体重低与孕产妇疾病活动显著相关（P<0.001，P<0.05）。我们得出结论：（1）计划生育妊娠应在疾病活动期用小剂量皮质类固醇良好控制至少6个月后进行。（2） 对狼疮患者来说，在产前和产后仔细监测疾病活动对于成功分娩至关重要。
