迟发型超敏反应。II. 通过抗原-抗体复合物在豚鼠中诱导超敏反应。
Delayed hypersensitivity. II. Induction of hypersensitivity in guinea pigs by means of antigen-antibody complexes.
作者信息
PAPPENHEIMER A M, SALVIN S B, UHR J W
出版信息
J Exp Med. 1957 Jan 1;105(1):11-24. doi: 10.1084/jem.105.1.11.
Abstract
A general method for induction of the delayed hypersensitive state directed against single protein antigens is described. The method consists of intradermal injection of minute amounts of washed immune precipitates containing the antigen in question. Provided the specific precipitates are formed in the region of antibody excess, maximal sensitivity develops at least 2 to 3 weeks before detectable circulating antibody is formed in guinea pigs against the sensitizing antigen. Neither adjuvant nor killed acid-fast bacteria are required for induction of the delayed hypersensitive state although the degree of sensitization is considerably increased when the sensitizing material is incorporated in Freund's complete adjuvant. Characteristics of the "delayed" as opposed to the "immediate" hypersensitive states in the guinea pig are described and implications of the findings are discussed.
摘要
本文描述了一种针对单一蛋白质抗原诱导迟发型超敏反应状态的通用方法。该方法包括皮内注射微量含有相关抗原的洗涤过的免疫沉淀物。如果特异性沉淀物在抗体过量区域形成，在豚鼠体内针对致敏抗原形成可检测到的循环抗体之前至少2至3周，会产生最大敏感性。诱导迟发型超敏反应状态既不需要佐剂也不需要灭活的抗酸菌，不过当致敏物质与弗氏完全佐剂混合时，致敏程度会显著增加。文中描述了豚鼠中“迟发”与“速发”超敏反应状态的特征，并讨论了这些发现的意义。
相似文献
1
Delayed hypersensitivity. II. Induction of hypersensitivity in guinea pigs by means of antigen-antibody complexes.迟发型超敏反应。II. 通过抗原-抗体复合物在豚鼠中诱导超敏反应。
J Exp Med. 1957 Jan 1;105(1):11-24. doi: 10.1084/jem.105.1.11.
2
Inhibition of delayed hypersensitivity in guinea-pigs after competition between synthetic antigens.合成抗原竞争后豚鼠迟发型超敏反应的抑制
Nature. 1967 Feb 18;213(5077):711-3. doi: 10.1038/213711a0.
3
Induction of delayed-type hypersensitivity to staphylococcal antigens in guinea pigs.豚鼠对葡萄球菌抗原迟发型超敏反应的诱导。
J Invest Dermatol. 1978 Aug;71(2):122-5. doi: 10.1111/1523-1747.ep12546488.
4
THE SPECIFICITY OF ALLERGIC REACTIONS. VII. IMMUNOLOGIC UNRESPONSIVENSSS, DELAYED HYPERSENSITIVITY, AND CIRCULATING ANTIBODY TO PROTEINS AND HAPTEN-PROTEIN CONJUGATES IN ADULT GUINEA PIGS.过敏反应的特异性。VII. 成年豚鼠对蛋白质和半抗原 - 蛋白质结合物的免疫无反应性、迟发型超敏反应及循环抗体
J Exp Med. 1964 May 1;119(5):851-68. doi: 10.1084/jem.119.5.851.
5
THE CUTANEOUS REACTIVITY OF GUINEA PIGS TO PURE. PROTEIN ANTIGENS. II. THE EFFECTS OF DIFFERENT ROUTES OF INJECTION OF ANTIGEN AND ADJUVANT.豚鼠对纯蛋白抗原的皮肤反应性。II. 抗原和佐剂不同注射途径的影响。
Int Arch Allergy Appl Immunol. 1964;25:315-23. doi: 10.1159/000229534.
6
7
8
INDUCED UNRESPONSIVENESS TO SIMPLE ALLERGENIC CHEMICALS. II. INDEPENDENCE OF DELAYED-TYPE HYPERSENSITIVITY AND FORMATION OF CIRCULATING ANTIBODY.对简单变应原化学物质的诱导无反应性。II. 迟发型超敏反应与循环抗体形成的独立性
J Exp Med. 1965 Apr 1;121(4):591-606. doi: 10.1084/jem.121.4.591.
9
Delayed type hypersensitivity to Staphylococcus aureus peptidoglycan in guinea pigs.豚鼠对金黄色葡萄球菌肽聚糖的迟发型超敏反应。
Zentralbl Bakteriol Orig A. 1978 Apr;240(2):165-70.
10
Delayed hypersensitivity. III. Specific desensitization of guinea pigs sensitized to protein antigens.迟发型超敏反应。III. 对蛋白质抗原有致敏反应的豚鼠的特异性脱敏
J Exp Med. 1958 Dec 1;108(6):891-904. doi: 10.1084/jem.108.6.891.
引用本文的文献
1
Susceptibility of neonate mice born to Schistosoma mansoni-infected and noninfected mothers to subsequent S. mansoni infection.曼氏血吸虫感染和未感染的母亲所生新生小鼠对后续曼氏血吸虫感染的易感性。
Parasitol Res. 2006 Jul;99(2):137-45. doi: 10.1007/s00436-006-0127-x. Epub 2006 Mar 7.
2
Mucosal vaccines: the promise and the challenge.黏膜疫苗：前景与挑战
Nat Rev Immunol. 2006 Feb;6(2):148-58. doi: 10.1038/nri1777.
3
Hypersensitivity in newborn guinea pigs.新生豚鼠的超敏反应。
J Exp Med. 1962 Apr 1;115(4):707-22. doi: 10.1084/jem.115.4.707.
4
Role of the thymus in immune ractions in rats. I. The immunologic response to bovine serum albumin (antibody formation, Arthus reactivity, and delayed hypersensitivity) in rats thymectomized or splenectomized at various times after birth.胸腺在大鼠免疫反应中的作用。I. 出生后不同时间进行胸腺切除或脾切除的大鼠对牛血清白蛋白的免疫反应（抗体形成、阿瑟斯反应和迟发型超敏反应）
J Exp Med. 1962 Aug 1;116(2):159-76. doi: 10.1084/jem.116.2.159.
5
6
7
The use of specific "lymphocyte" antisera to inhibit hypersensitive reactions of the "delayed" type.使用特异性“淋巴细胞”抗血清抑制“迟发型”超敏反应。
J Exp Med. 1961 Dec 1;114(6):997-1022. doi: 10.1084/jem.114.6.997.
8
The in vitro production of antibody by delayed phase corneal limbal lymphoid foci.迟发性角膜缘淋巴样病灶的抗体体外产生
J Exp Med. 1963 Feb 1;117(2):197-212. doi: 10.1084/jem.117.2.197.
9
[The antiglobulin consumption test. Its theoretical principles, technic and area of application].[抗球蛋白消耗试验。其理论原理、技术及应用领域]
Klin Wochenschr. 1962 Jun 15;40:613-22. doi: 10.1007/BF01479066.
10
Auto-immune disease. I. Modern immunological concepts.自身免疫性疾病。一、现代免疫学概念。
Br Med J. 1959 Oct 10;2(5153):645-50. doi: 10.1136/bmj.2.5153.645.
本文引用的文献
1
QUANTITATIVE EXPERIMENTS WITH ANTIBODIES TO A SPECIFIC PRECIPITATE. I.抗特定沉淀素的定量实验。一。
J Exp Med. 1941 Jan 1;73(1):125-40. doi: 10.1084/jem.73.1.125.
2
STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS : VII. SKIN SENSITIZATION BY INTRAPERITONEAL INJECTIONS.动物简单化学物致敏作用的研究：VII. 腹腔内注射致皮肤致敏。
J Exp Med. 1940 Jan 31;71(2):237-45. doi: 10.1084/jem.71.2.237.
3
Use of ultraviolet absorption spectroscopy in the quantitative precipitin reaction.紫外吸收光谱法在定量沉淀素反应中的应用。
J Immunol. 1949 Aug;62(4):437-51.
4
A quantitative study of the Arthus phenomenon induced passively in the guinea pig.对豚鼠被动诱发的阿瑟斯现象的定量研究。
J Immunol. 1950 Jan;64(1):1-19.
5
Immunochemical studies of antitoxin produced in normal and allergic individuals hyperimmunized with diphtheria toxoid. II. A comparison between the immunological properties of precipitating and non-precipitating (skin-sensitizing) antitoxins.对白喉类毒素进行超免疫的正常个体和过敏个体所产生抗毒素的免疫化学研究。II. 沉淀性抗毒素与非沉淀性（皮肤致敏）抗毒素免疫特性的比较。
J Exp Med. 1952 Apr;95(4):375-92. doi: 10.1084/jem.95.4.375.
6
Elicitation of delayed allergic skin reactions with haptens; the dependence of elicitation on hapten combination with protein.用半抗原引发迟发性过敏性皮肤反应；引发反应对半抗原与蛋白质结合的依赖性。
J Exp Med. 1952 May 1;95(5):473-87. doi: 10.1084/jem.95.5.473.
7
The active immunization of guinea-pigs passively immunized with homologous antitoxic serum.用同源抗毒素血清进行过被动免疫的豚鼠的主动免疫。
J Hyg (Lond). 1955 Jun;53(2):172-9. doi: 10.1017/s0022172400000644.
8
Passive cellular transfer of hypersensitivity to serum antigens in rabbits.家兔血清抗原超敏反应的被动细胞转移
J Immunol. 1955 Feb;74(2):96-100.
9
Delayed hypersensitivity. I. Induction of hypersensitivity to diphtheria toxin in guinea pigs by infection with Corynebacterium diphtheriae.迟发型超敏反应。一、通过感染白喉棒状杆菌在豚鼠中诱导对白喉毒素的超敏反应。
J Exp Med. 1957 Jan 1;105(1):1-9. doi: 10.1084/jem.105.1.1.
10
Transfer of delayed hypersensitivity to diphtheria toxin in man.人对白喉毒素迟发型超敏反应的转移
J Exp Med. 1956 Sep 1;104(3):321-35. doi: 10.1084/jem.104.3.321.
Zotero 插件