Walker B A, Ward P A
Department of Pathology, Vancouver General Hospital, BC, Canada.
Biol Signals. 1992 Sep-Oct;1(5):237-49. doi: 10.1159/000109329.
The priming response is a common feature for almost all agents which activate neutrophils. The priming response is associated with a number of events such as degranulation, receptor upregulation, increases in [Ca2+]i and the production of lipid second messengers. For each of these associated events there are data to suggest that priming can also occur in their absence. These contradictions suggest that either the true mechanism for priming has not been found or that there are multiple pathways by which the primed state can be reached. The latter is more likely to be the case.
引发反应是几乎所有激活中性粒细胞的因子所共有的特征。引发反应与许多事件相关，如脱颗粒、受体上调、细胞内钙离子浓度（[Ca2+]i）升高以及脂质第二信使的产生。对于这些相关事件中的每一个，都有数据表明在其不存在的情况下也可能发生引发。这些矛盾表明，要么尚未找到引发的真正机制，要么存在多种途径可达到引发状态。后一种情况更有可能。
