Han Y, Yin Q
Laboratory of Neurobiology, Suzhou Medical Collge, Jiangsu.
Zhen Ci Yan Jiu. 1992;17(3):161-5.
In this experiment, the role of PVN in acupuncture analgesia was further investigated with electrophysiological technique. In wistar rats the unit discharge was recorded extracellularly, Noxious stimulation was applied to sciatic nerve, and the electroacupuncture was performed on acupoints "Zusanli" and "Sanyinjiao". Totally eighty-two units were recorded successfully from PVN. 49 units of them reacted to electroacupuncture with excitatory (14), inhibitory (23) or on significant effect (12). Various types of reactions including excitation (12), inhibition (6), excito-inhibition (4) or inhibito-excitation (3) were observed on 43 units during noxious stimulation of sciatic nerve. The remainder 18 units had no significant reaction. After electroacupuncture those units reacting with excitatory effect on noxious stimulation decreased their firing rate, and those with inhibitory effect increased their firing rate. The duration of nociceptive reaction was shortened after electroacupuncture in both types of units. It was suggested that electroacupuncture could influence the activities and decrease the nociceptive reactions of PVN neurons, which might be considered as electrophysiological evidence of the involvement of PVN in acupuncture analgesia.
在本实验中，采用电生理技术进一步研究了下丘脑室旁核（PVN）在针刺镇痛中的作用。在Wistar大鼠上，细胞外记录单位放电，对坐骨神经施加伤害性刺激，并针刺“足三里”和“三阴交”穴位。从PVN成功记录到82个单位。其中49个单位对电针有反应，包括兴奋（14个）、抑制（23个）或无显著效应（12个）。在坐骨神经伤害性刺激期间，43个单位观察到各种类型的反应，包括兴奋（12个）、抑制（6个）、兴奋-抑制（4个）或抑制-兴奋（3个）。其余18个单位无显著反应。电针后，那些对伤害性刺激有兴奋作用的单位放电频率降低，而有抑制作用的单位放电频率增加。两种类型的单位在电针后伤害性反应的持续时间均缩短。提示电针可影响PVN神经元的活动并减少其伤害性反应，这可能被视为PVN参与针刺镇痛的电生理证据。
