He X, Zhu B, Liu X, Zhang S, Xu W
Institute of Acupuncture and Moxibustion, China Academy of Traditional Chinese Medicine, Beijing.
Zhen Ci Yan Jiu. 1993;18(4):271-5.
The experiments were performed in anaesthetized rats. The responses of convergent neurons in spinal dorsal horn to noxious stimuli (10mA, 2ms) given at the hindpaw receptive field were recorded extracellularly by glass microelectrodes. The effects of EA on the nociceptive response were observed. EA was applied on ipsilateral "Zusanli" or "Xiaguan" point with high and low intensity. EA (18V, 100Hz) applied on ipsilateral either "Zusanli" or "Xiaguan" could produce strong inhibition on nociceptive responses of convergent neurones (62.74 +/- 4.94% and 64.24 +/- 7.30%). EA (2V, 100Hz) of "Zusanli" also obviously inhibited the nociceptive responses (52.05 +/- 6.69%). But the same EA of "Xiaguan" lacked this inhibitory effect (9.50 +/- 7.67%). There was statistically significant difference between EA effects of "Zusanli" and "Xiaguan" (P < 0.001) when intensity of EA is lower. These results suggested that analgesia of high intensity EA is extensive, but that of low intensity EA is produced only when the point is in the same or nearby spinal segment with nociceptive field, showing the extensiveness and specificity of EA analgesia of different points.
实验在麻醉大鼠身上进行。用玻璃微电极细胞外记录脊髓背角汇聚神经元对后爪感受野施加的伤害性刺激(10mA,2ms)的反应。观察电针对伤害性反应的影响。电针分别以高低强度刺激同侧“足三里”或“下关”穴。对同侧“足三里”或“下关”施加18V、100Hz的电针可对汇聚神经元的伤害性反应产生强烈抑制(分别为62.74±4.94%和64.24±7.30%)。对“足三里”施加2V、100Hz的电针也能明显抑制伤害性反应(52.05±6.69%)。但对“下关”施加同样强度的电针则缺乏这种抑制作用(9.50±7.67%)。当电针强度较低时,“足三里”和“下关”的电针效应存在统计学显著差异(P<0.001)。这些结果表明,高强度电针镇痛作用广泛,但低强度电针镇痛仅在穴位与伤害性刺激区域位于同一或附近脊髓节段时才产生,显示了不同穴位电针镇痛的广泛性和特异性。