Omotainse S O, Anosa V O
Nigerian Institute for Trypanosomiasis Research, Plateau State.
Rev Elev Med Vet Pays Trop. 1992;45(3-4):279-83.
Trypanosoma brucei infection produced an acute and fatal disease in Nigerian mongrel dogs due to a rapidly developing anaemia. Infected dogs responded with increased reticulocytosis, which was not sustained with chronicity. In comparison the response to artificially-induced haemolytic anaemia was progressive, marked and sustained. The anaemia of T. brucei infection of dogs was either normocytic normochromic in acute infection or microcytic normochromic in chronic infection. Artificially-induced haemolytic anaemia was either macrocytic normochromic or normocytic normochromic. The erythropoietic potential of plasma in vivo in mice increased in T. brucei-infected dogs except at the terminal parasitaemia. The anaemia in Trypanosoma brucei-infected dogs is therefore initially responsive but becomes poorly involved with chronicity.
布氏锥虫感染在尼日利亚杂种犬中引发了一种急性致命疾病，原因是贫血迅速发展。受感染的犬只出现网织红细胞增多反应，但随着病情慢性化，这种反应并未持续。相比之下，对人工诱导的溶血性贫血的反应是渐进性的、显著的且持续的。犬只感染布氏锥虫后的贫血在急性感染时为正细胞正色素性，在慢性感染时为小细胞正色素性。人工诱导的溶血性贫血则为大细胞正色素性或正细胞正色素性。除了在终末期寄生虫血症阶段外，布氏锥虫感染犬体内小鼠血浆的促红细胞生成潜能增加。因此，布氏锥虫感染犬的贫血最初有反应，但随着病情慢性化，反应变得微弱。
