Herbrecht R, Liu K L, Koenig H, Waller J, Dufour P, Marcellin L, Maloisel F
Service d'Onco-Hématologie, Hôpital de Hautepierre, Strasbourg.
Agressologie. 1992;33 Spec No 2:96-8.
Invasive Trichosporon capitatum infections are seldom reported. We present here five cases of septicemia. All patients had an acute myeloblastic leukemia and were severely neutropenic. They have also been treated before the onset of the fungal infection with broad-spectrum antibiotherapy and also with an oral azole antifungal agent. The role of this antifungal therapy in the development of T. capitatum infection is discussed. The prognosis of T. capitatum infections is severe. Eight of the 10 published cases had a fatal outcome and one of our patients died of the fungal infection in spite of the treatment.
侵袭性头状毛孢子菌感染鲜有报道。我们在此报告5例败血症病例。所有患者均患有急性髓细胞白血病且严重中性粒细胞减少。在真菌感染发作前,他们还接受了广谱抗生素治疗以及口服唑类抗真菌药物治疗。本文讨论了这种抗真菌治疗在头状毛孢子菌感染发生中的作用。头状毛孢子菌感染的预后严重。已发表的10例病例中有8例死亡,我们的1例患者尽管接受了治疗仍死于真菌感染。