Liu K L, Herbrecht R, Bergerat J P, Koenig H, Waller J, Oberling F
Service d'Onco-Hématologie, CHU de Hautepierre, Strasbourg, France.
Bone Marrow Transplant. 1990 Sep;6(3):219-21.
A case of disseminated infection with Trichosporon capitatum is reported in a 23-year-old patient with acute myeloid leukemia undergoing HLA-mismatched bone marrow transplantation. He was receiving immunosuppressive therapy with cyclosporine and corticosteroids for acute graft-versus-host disease and he was severely neutropenic. While being treated with fluconazole for 28 days for an oropharyngeal candidiasis the patient developed a T. capitatum septicemia. He died despite receiving amphotericin B therapy. Autopsy revealed widespread infection with T. capitatum. The portal of entry was probably the digestive tract in this patient as T. capitatum had been first isolated in the stools.
报告了一例23岁急性髓系白血病患者在接受HLA配型不合的骨髓移植后发生头状毛孢子菌播散性感染的病例。该患者因急性移植物抗宿主病接受环孢素和皮质类固醇免疫抑制治疗，且严重中性粒细胞减少。在因口咽念珠菌病接受氟康唑治疗28天时，患者发生了头状毛孢子菌败血症。尽管接受了两性霉素B治疗，患者仍死亡。尸检显示头状毛孢子菌广泛感染。由于头状毛孢子菌最初是在粪便中分离出来的，该患者的感染入口可能是消化道。
