Israil A
Institutul Cantacuzino R.A, Bucureşti.
Bacteriol Virusol Parazitol Epidemiol. 1992 Jul-Dec;37(3-4):1-8.
Lantibiotics synthesized by gram positive bacteria (Staphylococcus, Streptococcus, Bacillus, genera) are a special group of polycyclic polypeptides constituted of protein amino acids and unusual amino acids (i.e. lanthionine, beta-methyllantionine etc.) these last ones exhibiting interchain thioeter bridges and ring structures. Some lantibiotics are already used in medical therapy (nisin, gallidermin, epidermin) as well as for food preservation (nisin). Their special structures and synthesis have focused substantial scientific interest, the lantibiotics proving to be ideal experimental models not only for microbiology but also for biochemistry, molecular biology, gene technology and protein engineering in the purpose to get more insights in the fundamental aspects of the cell biology.
革兰氏阳性菌（葡萄球菌属、链球菌属、芽孢杆菌属等）合成的羊毛硫抗生素是一类特殊的多环多肽，由蛋白质氨基酸和特殊氨基酸（即羊毛硫氨酸、β-甲基羊毛硫氨酸等）组成，这些特殊氨基酸具有链间硫酯桥和环状结构。一些羊毛硫抗生素已用于医学治疗（乳链菌肽、加里道霉素、表皮溶素）以及食品保鲜（乳链菌肽）。它们独特的结构和合成方法引起了科学界的广泛关注，事实证明，羊毛硫抗生素不仅是微生物学，也是生物化学、分子生物学、基因技术和蛋白质工程的理想实验模型，有助于更深入地了解细胞生物学的基本方面。
